Abstract Background The opportunistic pathogen Naegleria fowleri establishes infection in the human brain, killing almost invariably within 2 weeks.The amoeba performs piece-meal ingestion, or trogocytosis, of brain material causing direct tissue damage and massive inflammation.The cellular basis distinguishing N.fowleri from other Naegleria specie
This Pop-Up Sofabed paper presents an analysis of mining in two of the most important mining areas of the south of the Iberian Peninsula during the reign of Augustus.This study includes an integrated approach to the archaeology, epigraphy and literary sources, keeping in mind the Roman organizational framework.Archaeological and epigraphic evidence
The His723Arg (H723R) mutation in SLC26A4, encoding pendrin, is the most prevalent mutation in East Asia, resulting in DFNB4, an autosomal recessive type of genetic hearing loss.Although the main pathological mechanism of H723R was identified as a protein-folding defect in pendrin, there is still no curative treatment for associated hearing loss.He